Alcohol, prescription, and over-the-counter medications, inhalants and solvents, and even coffee and cigarettes can all be used to harmful excess. Many children have their first encounter with substance misuse by using inhalants, simply because they are found in many common household products and, therefore, readily available.

Alcohol.

Alcohol is legal for adults over the age of 21 in the United States. However, it doesn't take much alcohol to reach a harmful level of drinking, and that is when alcohol use can turn into alcohol abuse.

Drinking five or more drinks for men (four for women) in any one sitting is considered binge drinking, which can be harmful to your physical and mental health in many different ways.

Nicotine.

Nicotine is the single most abused substance in the world.

Again, just because it is legal, doesn't mean it can't be abused. The fact that the negative health effects of nicotine take a long time to manifest probably plays a role in the widespread abuse of tobacco.

➡️Caffeine.

Whereas nicotine is the most abused drug, caffeine is the most commonly used mood altering drug in the world. And yes, too much caffeine can be harmful to your health.

Studies have also found a link between caffeine use and several psychiatric syndromes, including caffeine induced sleep disorder and caffeine induced anxiety disorder.

➡️Synthetics.

So-called "designer drugs" and synthetic drugs, such as bath salts and synthetic marijuana, can be abused and can possibly be more dangerous than other drugs.

➡️Anabolic Steroids.

Anabolic steroids have no mood-altering or intoxicating properties, but they can still be misused. Using anabolic steroids to enhance performance or develop muscles and strength is abusive because of the negative side effects of steroid use.

These can range from merely annoying to life-threatening in some cases.14 If using a substance can cause you harm, it is substance abuse. Theoretically, almost any substance can be abused.

Sources - https://www.verywellmind.com/substance-use-4014640

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https://americanaddictioncenters.org/blog/the-5-most-commonly-abused-drugs-in-college