General Colin Powell, the first Black US secretary of state whose leadership in several Republican administrations helped shape American foreign policy in the last years of the 20th century and the early years of the 21st, has died from complications from Covid-19, his family said on Facebook. He was 84.

"General Colin L. Powell, former U.S. Secretary of State and Chairman of the Joint Chiefs of Staff, passed away this morning due to complications from Covid 19," the Powell family wrote on Facebook, noting he was fully vaccinated.

Powell had multiple myeloma, a cancer of plasma cells that suppresses the body's immune response, as well as Parkinson's, Peggy Cifrino, Powell's longtime chief of staff, confirmed to CNN. Even if fully vaccinated against Covid-19, those who are immunocompromised are at greater risk from the virus.

"We have lost a remarkable and loving husband, father, grandfather and a great American," the family said.

Powell was a distinguished and trailblazing professional soldier whose career took him from combat duty in Vietnam to becoming the first Black national security adviser during the end of Ronald Reagan's presidency and the youngest and first African American chairman of the Joint Chiefs of Staff under President George H.W. Bush. His national popularity soared in the aftermath of the US-led coalition victory during the Gulf War.