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Abstract
Diabetes mellitus (DM) confers an increased risk of sudden cardiac death (SCD) independent of its associated cardiovascular comorbidities. Diabetes mellitus induces adverse structural, electrophysiological, and autonomic cardiac remodeling which can increase one’s risk of ventricular arrhythmias and SCD. Although glycemic control and prevention of microvascular and macrovascular complications are cornerstones in the management of DM, they are not adequate for the prevention of SCD. In this narrative review, we describe the contribution of DM to the pathophysiology of SCD beyond its role in atherosclerotic cardiovascular disease and heart failure. Based on this pathophysiological framework, we outline potential preventive and therapeutic strategies to mitigate the risk of SCD in this high-risk patient population.
Sources - https://www.sciencedirect.com/science/article/abs/pii/S1547527124026766