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You know it isn't that easy to get acclimated to a new situation or milieu so easily.
The common reason behind that is that people adapt to their surroundings and dwell in their comfort zone, thinking outside that zone brings stress and anxiety.
There's a specific disorder to explain it, and it is called adjustment disorder.
Mostly, it is not the small changes that a person can't adjust to; instead, some major life changes can evoke a sense of gloominess.
Like the death of a loved one or moving to a new city, both situations are different but can lead to some major adjustment anxiety issues.
It is quite apparent and genuine to adjust to a new situation, but if the feelings of sadness and non-acceptance persist, it can be a sign of serious disorder.
And here, you need to talk and vent things out to get help.